BOX-BEHNKEN DESIGN FOR OPTIMIZATION OF FORMULATION VARIABLES FOR CONTROLLED RELEASE GASTRORETENTIVE TABLET OF VERAPAMIL HYDROCHLORIDE

Objective: To develop a Verapamil hydrochloride controlled release gastro-retentive (CRGR) tablet for once-daily dosing using the response surface Box-Behnken Design (BBD) approach improvement of bioavailability and reduction in frequency to overcome issues related conventional formulation. Methods: For optimization, 33Box-Behnken design was used. The independent variables were selected, amount Compritol 888 ATO (A), HPMC K15M (B), Sodium bicarbonate (C). dependent Cumulative % drug 1.5 h (Q1.5), 8 (Q8), 24 H (Q24) floating lag time (FLT). Flow properties pre-compressed powder, physical characteristics, content, time, total vitro dissolution study all formulation assessed. In optimized that prepared experimentally performed compared with predicted data obtained from software. Drug kinetics also assessed know mechanism CRGR tablets. Results: Responses experimental runs found as Q1.5: 12.78-33.62 (%), Q8: 43.03-64 Q24: 78.77 103.57 (%) 3.01 min 5.08 min. formula highest desirability value 0.963 containing 126.030 mg, 160.00 mg 80.955 ATO, biarbonate respectively evaluated. values 23.397%, Q8; 57.744%, 97.150% FLT: 3.12 Predicted results comparable responses. best fitted Higuchi (r2 = 0.999) Korsmeyer-Peppas ((r2 0.998, n=0.54) model. studies indicated gastroretentive releases manner h. Conclusion: This variable relation, it is possible achieve an optimum desirable characteristics. established suitability ATO-HPMC combination increase gastric residence had Hcl improved effective management hypertension.